This one does work both ways but not for weekends. Look at via LAX for best MQMs and miles. For a weekend you can fly out after work Friday and redeye back and still have your weekend. Here are the numbers:
6,247MQMs at 4.2CPM
Bookable on Delta.com
DM yields a very nice 14,057 Skymiles per CWSI.net!
Again FROM LAS even better yields but weekday only runs but as low as 3.8CPM!
ALERT: Routing TO/FROM SEA can drive price as low as 3.2CPM! Look for other city’s please!