No fear of ZIKA if you do not leave the airport right ;-)! I am not a huge fan of red-eyes anymore but if you are a DTW hub captive this is a very nice run in first class at a price I would be willing to pay in coach that is sub 5CPM from a Delta hub.
You can tinker with dates on this one as well as connections as if you take the one with the longer layover in MCO you can visit THE CLUB at MCO and get a shower before your return or even look at an overnight if you do not want to red-eye.
I have also included the coach BASIC EVIL E fare that does earn FULL POINTS but for the price I would pass and buy in 1st class. I have also included in SEPTEMBER one date that works at a higher price but for a weekend run if you can not run on a weekday. BTW I would book fast if you want this as I doubt it will last long!
Here are the numbers I found (via SLC both ways):
Cost: $489 in 1st class
10,232 MQMs at 4.8 CPM
Weekday in 1st class <-LINK
Weekend in 1st class <-LINK
Weekday in EVIL BASIC E class (warning NO upgrades) <-LINK
EDIT: Works from MSP for a few bucks more! <-LINK
I have included the Google Flights or Kayak links and for those of you new to this, 1st log in to your Delta.com SkyMiles account and THEN you click the above links and it will, after you choose flights, send them over to Delta.com. Very simple! – René